Author

Deborah K. Lieu

University of California, DavisORCID 0000-0002-3765-3203Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1

Frequent Co-Authors

Luis Fernando SantanaiD· 2 shared Regan L. Smithers· 2 shared Alice Cheung· 1 shared Andy O.-T. Wong· 1 shared Anna WalentinssoniD· 1 shared Cláudia CorreiaiD· 1 shared Colleen E. ClancyiD· 1 shared David Cameron· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Luis Fernando SantanaORCID

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Author profile →

3 papers

Recent·Most cited

Quantitative Head-to-Tail Analysis Reveals Heterogeneous Cellular Organization and Connexin Expression in the Porcine Sinoatrial Node

Hillary K. J. Kao, Regan L. Smithers, David H. Ramos-Rodriguez, Kaitlin Van Brusselen, Rableen Kaleka, David Cameron, Jan A. Nolta, Kyle Fink, J. Kent Leach, L. Fernando Santana, Nipavan Chiamvimonvat, Deborah K. Lieu

The paper quantifies cellular organization and connexin expression in the porcine sinoatrial node, revealing regional differences in pacemaking function and current source-sink relationships.

bioRxiv · Nov 9, 2026 · PreprintCell Biology

Large-scale synthetic data enable digital twins of human excitable cells

Pei‐Chi Yang, Mao-Tsuen Jeng, Deborah K. Lieu, Regan L. Smithers, Gonzalo Hernandez-Hernandez, Luis Fernando Santana, Colleen E. Clancy

The paper uses synthetic data to create digital twins of human cardiomyocytes, enabling precise modeling of electrophysiological properties from experimental recordings.

bioRxiv · Sep 3, 2025Pharmacology & Toxicology

Reversal of contractile defects by mediating calcium homeostasis in human mini-heart models of heart failure with preserved ejection fraction (HFpEF) leads to first-in-human gene therapy clinical trial

Kevin D. Costa, Andy O.-T. Wong, Suet Yee Mak, Erin G. Roberts, Wendy Keung, Cláudia Correia, Anna Walentinsson, Jonas Christoffersson, Alice Cheung, Deborah K. Lieu, Karin Jennbacken, Qing‐Dong Wang, Roger J. Hajjar, Ronald A. Li

This paper develops human mini-heart models of HFpEF, identifies SERCA2a downregulation, and demonstrates gene therapy efficacy, leading to a first-in-human clinical trial.

bioRxiv · Aug 27, 2024 · PreprintBioengineering