Antonio Gentilella

Pharmacologic decoupling of IRBC activation from anabolic collapse redefines ribosome biogenesis inhibition as a selective tumor suppressive strategy

This study shows that inhibiting ribosome biogenesis can selectively activate the IRBC checkpoint in TP53-proficient cells, offering a new therapeutic strategy for cancer.

LARP1 integrates MYC and mTOR signaling to enable anabolic growth during tumor initiation

This study identifies LARP1 as a critical effector linking MYC and mTOR signaling in tumor initiation, showing its role in translating MYC-driven anabolic programs under metabolic permissiveness.