Author

Sean N. McMillan

University of LeedsORCID 0000-0002-6833-5523Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Bipasha BaruaiD· 1 shared Charlotte A. ScarffiD· 1 shared Donald A. WinkelmanniD· 1 shared Jaime R T PittsiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

Bipasha BaruaORCID

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1 paper

Recent·Most cited

Mavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation

Sean N. McMillan, Jaime R T Pitts, Bipasha Barua, Donald A. Winkelmann, Charlotte A. Scarff

This paper investigates how mavacamten inhibits myosin activity by stabilizing the interacting-heads motif and affecting cardiac muscle relaxation and contraction.

bioRxiv · Feb 12, 2025 · PreprintBiochemistry