Bipasha Barua

This paper investigates the HCM mutation M493I in β-cardiac myosin, showing it disrupts the super-relaxed state, slows ADP release, and enhances actin attachment and force production, leading to hypercontractility.

This paper identifies a novel epitope (S2Tag) recognized by an antibody that effectively tethers coiled-coil proteins, demonstrating its utility in studying β-cardiac myosin mechanics and disease mutations.

This paper investigates how mavacamten inhibits myosin activity by stabilizing the interacting-heads motif and affecting cardiac muscle relaxation and contraction.