AN OPTIMIZED AND DRUGGABLE HUMAN KERATINOCYTE AND IPSC-DERIVED SENSORY NEURON CO-CULTURE SYSTEM FOR ATOPIC ITCH
Hendrik Mießner, Benjamin Al, Hendrik Reuter, Judith Seidel, Ewan St. John Smith
This paper develops a co-culture system of human keratinocytes and iPSC-derived sensory neurons to model AD itch, showing TRPA1 and JAK1/2 inhibition reduce pruritogen responses.
bioRxiv · May 13, 2026 · PreprintNeuroscience