Tau conformers in FTLD-MAPT undergo liquid-liquid phase separation and perturb the nuclear envelope
Sang‐Gyun Kang, Zhuang Zhuang Han, Nathalie Daude, Emily McNamara, Serene L. Wohlgemuth, Jiri Safar, Sue‐Ann Mok, David A. Westaway
The paper shows that tau conformers in FTLD-MAPT undergo liquid-liquid phase separation and disrupt nuclear envelope function, leading to cell death and fibrillar structures.
bioRxiv · Jul 4, 2020 · PreprintNeuroscience