Zhuang Zhuang Han

Open-source Python package parses Axion spk files directly and matches NeuralMetric Tool outputs, then reveals burst and network burst hyperexcitability, without synchrony change, in LGI2-knockdown human iPSC neurons.

The paper shows that sialylated gangliosides are essential for plasma membrane organization and neuronal function, with ST3GAL5 deficiency causing severe disruptions in glycosphingolipid composition and neuronal activity.

This study functionally and pharmacologically characterizes the store-operated calcium entry pathway in naked mole-rat cells using both excitable and non-excitable cells.

The paper shows that tau conformers in FTLD-MAPT undergo liquid-liquid phase separation and disrupt nuclear envelope function, leading to cell death and fibrillar structures.