Mis-splicing Drives Loss of Function of p53E224D Point Mutation
Ian C. Lock, Nathan H. Leisenring, Warren Floyd, Eric S. Xu, Lixia Luo, Yan Ma, Erin C. Mansell, Diana Marcella Cardona, Chang‐Lung Lee, David G. Kirsch
The paper investigates a p53 mutation that causes mis-splicing and loss of function in vitro and in vivo, challenging the classical view of p53 tumor suppression.
PLoS ONE · Mar 5, 2025Peer-reviewedGenomics