Author

Ian C. Lock

Duke Medical CenterORCID 0000-0001-8247-4514Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Alexandre PuissantiD· 1 shared Amy E. StewartiD· 1 shared Ben Zolyomi· 1 shared Chang‐Lung LeeiD· 1 shared Christopher B. NewgardiD· 1 shared Christopher D. DelaneyiD· 1 shared Claudie BosciD· 1 shared David G. KirschiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Alexandre PuissantORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

GenomicsPLoS ONEPeer-reviewedMar 5, 2025

Mis-splicing Drives Loss of Function of p53E224D Point Mutation

Ian C. Lock, Nathan H. Leisenring, Warren Floyd…·David G. Kirsch

The paper investigates a p53 mutation that causes mis-splicing and loss of function in vitro and in vivo, challenging the classical view of p53 tumor suppression.

4 citations

mousehuman

𝕏 PostBluesky

Cancer BiologybioRxivPreprintFeb 26, 2025

Pathway Coessentiality Mapping Reveals Complex II is Required for de novo Purine Biosynthesis in Acute Myeloid Leukemia

Amy E. Stewart, Derek K. Zachman, Pol Castellano‐Escuder…·Matthew D. Hirschey

The paper identifies Complex II's role in de novo purine biosynthesis in AML using CRISPR and metabolomic data, showing it as a therapeutic target.

2 citations

mousemetabolomics

𝕏 PostBluesky