A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer
Amith Vikram Rangarajan, Ilona Sviezhentseva, Emma L. Gunderson, Yana Pikman, Matthew P. Jacobson, Beth Apsel Winger
The paper develops a structure-based tool to evaluate kinase mutations in cancer by aligning them with known activating mutations using structural and functional data.
Frontiers in Oncology · Aug 4, 2025Peer-reviewedCancer Biology