Author

Danian Chen

Lunenfeld-Tanenbaum Research InstituteORCID 0000-0002-6916-2978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:batch correction / integration· 1 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Caitlin F. HarriganiD· 1 shared Ching Yeung LamiD· 1 shared Christian Lai· 1 shared Fang LüiD· 1 shared Hartland Warren JacksoniD· 1 shared Hui Cheng· 1 shared Jianlu Xiao· 1 shared Jing SuiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioinformatics

Caitlin F. HarriganORCID

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2 papers

Recent·Most cited

Automated registration of spatial expression data scales multimodal integration to large cohorts

Caitlin F. Harrigan, Ching Yeung Lam, Danian Chen, Christian Lai, Rod Bremner, Hartland Warren Jackson, Kieran R. Campbell

The paper introduces a Bayesian optimization framework for automated registration of spatial expression data across modalities, achieving higher success rates on a large dataset of 954 image pairs.

bioRxiv · May 29, 2025 · PreprintBioinformatics

In vivo base editing rescues photoreceptors in a mouse model of retinitis pigmentosa

Jing Su, Kaiqin She, Li Song, Xiu Jin, Ruiting Li, Qinyu Zhao, Jianlu Xiao, Danian Chen, Hui Cheng, Fang Lü, Yuquan Wei, Yang Yang

This study uses base editing to correct a Pde6b mutation in a mouse model of retinitis pigmentosa, restoring photoreceptor function and visual ability.

Molecular Therapy — Nucleic Acids · Feb 14, 2023Peer-reviewedGenetics