Complete Protection Against Lethal Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Challenge in Mice Afforded by Immunization with Modified mRNA Encoding the Nucleocapsid Protein (NP) Alone
Sercan Keskin, Shaikh Terkıs Islam Pavel, Rabia Sak, Fatemeh Bahadorı, Ahmet Furkan Aslan, Münir Aktaş, Faruk Karakeçili, Ahmet Kalkan, Aykut Özdarendeli, Mehmet Ziya Doymaz
This paper shows that an mRNA vaccine encoding the CCHFV nucleocapsid protein provides 100% protection against lethal viral challenge in mice.
bioRxiv · Apr 21, 2025 · PreprintImmunology