A Statistical Framework to Identify Cell Types Whose Genetically Regulated Proportions are Associated with Complex Diseases
Wei Liu, Wenxuan Deng, Ming Chen, Zihan Dong, Biqing Zhu, Zhaolong Yu, Daiwei Tang, Maor Sauler, Chen Lin, Louise V. Wain, Michael H. Cho, Naftali Kaminski, Hongyu Zhao
This paper introduces a statistical framework, cWAS, to identify cell types with genetically regulated proportions associated with complex diseases using integrated genetic and transcriptomics data.
PLoS Genetics · Jul 31, 2023Peer-reviewedGenetic & Genomic Medicine