Sebastian Westenhoff

Visualizing Reaction Pathways via Reciprocal Space Kinetic Decomposition

The paper introduces a method to decompose time-resolved crystallography data in reciprocal space to extract weak transient structural states from noisy datasets.

XSSDense: Time-resolved X-ray Solution Scattering Density Reconstruction Using a Variational Autoencoder

XSSDense reconstructs electron density maps from X-ray scattering data using a variational autoencoder and genetic algorithm, capturing conformational heterogeneity in proteins.

Anaerobic time-resolved serial crystallography captures CO dissociation and rebinding in oxygen-sensitive -hydrogenase

This study uses anaerobic time-resolved serial crystallography to capture CO dissociation and rebinding in [FeFe]-hydrogenase, revealing a rigid catalytic architecture.

Chemical mechanism of allosteric and asymmetric dark reversion in a bacterial phytochrome uncovered by cryo-EM.

This paper uses cryo-EM to study dark reversion in PaBphP, revealing asymmetric reversion between protomers and structural mechanisms controlling the reaction.

Detection of a hybrid PrPfr state in the dark reversion of abathy phytochrome indicates inter-dimer allostery.

The paper investigates dark reversion kinetics of PaBphP phytochrome, finding evidence for an intermediate PrPfr state and inter-dimer allostery.

Cryo-EM structures of a bathy phytochrome histidine kinase reveal a unique light-dependent activation mechanism

The paper presents cryo-EM structures of PaBphP phytochrome in two states, revealing a unique light-dependent activation mechanism through structural changes.

cryoSPHERE: Single-particle heterogeneous reconstruction from cryo EM

The paper introduces cryoSPHERE, a deep learning method for heterogeneous cryo-EM reconstruction, improving upon state-of-the-art methods in three examples.