Lukas Grunewald

The paper introduces a method to decompose time-resolved crystallography data in reciprocal space to extract weak transient structural states from noisy datasets.

This study uses anaerobic time-resolved serial crystallography to capture CO dissociation and rebinding in [FeFe]-hydrogenase, revealing a rigid catalytic architecture.

The paper presents cryo-EM structures of PaBphP phytochrome in two states, revealing a unique light-dependent activation mechanism through structural changes.

The paper introduces cryoSPHERE, a deep learning method for heterogeneous cryo-EM reconstruction, improving upon state-of-the-art methods in three examples.