Topic modelling with ICD10-informed priors identifies novel genetic loci associated with multimorbidities in UK Biobank
Yidong Zhang, Xilin Jiang, Alexander J. Mentzer, Gil McVean, Gerton A. Lunter
The paper develops treeLFA, a topic modeling method using ICD10 priors to identify multimorbidity clusters in UK Biobank, and finds genetic loci associated with these clusters.
medRxiv · Oct 28, 2022 · PreprintGenetic & Genomic Medicine