Alexander J. Mentzer

Reconstructing donor genotypes from scRNA-seq for downstream eQTL and HLA-TCR analysis

This paper introduces scTAPAS, a method to reconstruct donor genotypes from scRNA-seq data, enabling eQTL and HLA-TCR analysis without conventional genotyping.

Multi-ancestry MHC-pQTL mapping reveals disease-linked HLA protein networks and shared genetic architecture

This study maps MHC-pQTL across ancestries, identifying genetic associations with plasma proteins and linking HLA genes to immune-related traits.

Mode of T cell priming durably shapes the TCR repertoire, effector function and α4β1 integrin expression of human virus-specific CD4+ T cells

This study compares how natural infection versus vaccination primes human CD4+ T cells, showing differences in TCR diversity, effector function, and integrin expression years later.

Genetic determinants of cytokine production in activated human monocytes

The paper identifies four genome-wide significant loci affecting monocyte cytokine release and links genetic variants to cytokine secretion patterns.

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children

The paper identifies African-specific genetic loci associated with iron status and risk of severe malaria and bacteremia in children, highlighting limited transferability of European polygenic risk scores.

Uncovering structural determinants of peptide recognition by public and private T-cell receptors

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.

Geographical variation drives adaptive equilibrium of the P. falciparum sickle-associated mutations

The paper investigates how geographical variation influences the adaptive evolution of Plasmodium falciparum mutations that counteract sickle cell trait protection.

Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infection

The paper identifies disease-specific genetic regulation of gene expression in immune cells during COVID-19 infection using single-cell eQTL mapping.

OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

An accurate genetic colocalization method for the HLA locus

This paper introduces HLA-colocalization, a method for genetic colocalization at the HLA locus using HLA alleles, showing it identifies novel causal associations between viruses and autoimmune diseases.

Genetic Susceptibility to Astrovirus Diarrhea in Bangladeshi Infants

This study identifies two genetic regions associated with astrovirus diarrhea susceptibility in Bangladeshi infants through a genome-wide association study.

Nationwide genomic biobank in Mexico unravels demographic history and complex trait architecture from 6,057 individuals

Targeting hepatitis B vaccine escape using immunogenetics in Bangladeshi infants

The paper identifies HLA variants associated with HBV vaccine response in Bangladeshi infants and links them to vaccine escape mechanisms.

Topic modelling with ICD10-informed priors identifies novel genetic loci associated with multimorbidities in UK Biobank

The paper develops treeLFA, a topic modeling method using ICD10 priors to identify multimorbidity clusters in UK Biobank, and finds genetic loci associated with these clusters.

Genome-wide association study of cryptosporidiosis in infants implicates PRKCA

This paper conducts a GWAS to identify genetic variants associated with symptomatic cryptosporidiosis in infants, finding a strong association with an intronic SNP in PRKCA.

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and Oceania

This study identifies five genome-wide associations with severe malaria risk in 17,000 individuals from Africa, Asia, and Oceania, including a new variant linked to cerebral malaria.

Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leukocyte antigen locus

The paper identifies an association between the HLA-DQA1*01:03 allele and increased risk of invasive group A streptococcal disease using case-control studies and HLA imputation.

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

The paper uses genome-wide association studies to show human and pneumococcal genetic variation influences susceptibility and severity of pneumococcal meningitis.

HLA*PRG:LA - HLA typing from linearly projected graph alignments

HLA*PRG:LA is a graph alignment model for HLA typing that achieves high accuracy across various sequencing data types.

Genome-Wide Association Study Reveals Genetic Link Between Diarrhea-Associated Entamoeba histolytica Infection And Inflammatory Bowel Disease

This study identifies genetic variants associated with Entamoeba histolytica infection and links them to inflammatory bowel disease susceptibility.

Population Turnover in Remote Oceania Shortly After Initial Settlement

The paper uses ancient DNA analysis to show that Papuan ancestry arrived in Vanuatu around 2400 BP, suggesting multiple waves of migration from Near Oceania.