Author

Matthias P. Machner

National Institutes of HealthORCID 0000-0002-6971-7451Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Anne Davidson Ward· 1 shared Jessica TungiD· 1 shared Katherine E. Bonnington· 1 shared Kathryn Johnston· 1 shared Kevin S. MyersiD· 1 shared Nicole A. EllisiD· 1 shared Timothy J. DonohueiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Anne Davidson Ward

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1 paper

Recent·Most cited

A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes

Nicole A. Ellis, Kevin S. Myers, Jessica Tung, Anne Davidson Ward, Kathryn Johnston, Katherine E. Bonnington, Timothy J. Donohue, Matthias P. Machner

The paper introduces MuRCiS, a CRISPRi-Seq method to identify gene combinations critical for virulence in L. pneumophila, finding that lpg2888 and lpg3000 have redundant roles in macrophages, while lpg3000 is essential in amoebae.

eLife · May 19, 2023Peer-reviewedGenetics