The paper introduces difference contact maps (DCMs) to analyze conformational flexibility in proteins by identifying critical interactions and functional residues across alternative conformations.

PLoS ONE · Mar 12, 2020Peer-reviewedBioinformatics

Unraveling Oxidative Stress Resistance: Molecular Properties Govern Proteome Vulnerability

Roger L. Chang, Julian A. Stanley, Matthew C. Robinson, Joel W. Sher, Zhanwen Li, Yujia A. Chan, Ashton R. Omdahl, Ruddy Wattiez, Adam Godzik, Sabine Matallana‐Surget

The paper identifies molecular properties that determine oxidative stress resistance in bacteria by analyzing protein susceptibility to oxidation in Escherichia coli and Deinococcus radiodurans.

bioRxiv · Mar 9, 2020 · PreprintSystems Biology

Cancer3D 2.0: interactive analysis of 3D patterns of cancer mutations in cancer subsets

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W. Post, Thomas Hrabe, Eduard Porta‐Pardo, Adam Godzik

Cancer3D 2.0 provides an interactive platform to analyze 3D mutation patterns in cancer subsets, enabling identification of novel driver regions in specific patient subgroups.

Nucleic Acids Research · Nov 7, 2018Peer-reviewedBioinformatics