Author

Matthew C. Robinson

Broad InstituteORCID 0009-0001-3935-9083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Organism:E. coli· 1

Frequent Co-Authors

Alpha A. LeeiD· 3 shared D. FearoniD· 3 shared F. von DelftiD· 3 shared Haim Michael BarriD· 3 shared Noa Lahav· 3 shared Tamás SzommeriD· 3 shared Annette von DelftiD· 2 shared Briana Lynn McGoverniD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

Alpha A. LeeORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivPreprintJun 19, 2025

Discovery of orally bioavailable Zika virus NS2B-NS3 protease inhibitors with efficacy in a murine infection model

Nathaniel T. Kenton, Haim Michael Barr, Artem Cherepakha…·Alpha A. Lee

The paper identifies orally bioavailable inhibitors of the Zika virus NS2B-NS3 protease that show antiviral activity in vitro and reduce viral RNA load in a murine infection model.

3 citations

mouseexperimental assay

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Pharmacology & ToxicologybioRxivPreprintJun 16, 2025

Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor

Ed Griffen, D. Fearon, Briana Lynn McGovern…·Annette von Delft

This paper describes the optimization of a SARS-CoV-2 Mpro inhibitor to address genotoxic and metabolic liabilities, leading to improved in vivo efficacy and exposure.

5 citations

mouseexperimental assay

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MicrobiologybioRxivPreprintAug 19, 2024

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response

Alpha A. Lee, Isabelle Amick, Jasmin Cara Aschenbrenner…·Max Winokan

The paper identifies potent nsp3-mac1 inhibitors but finds they do not translate to antiviral activity in cell culture models.

11 citations

humanproteomics

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Systems BiologybioRxivPreprintMar 9, 2020

Unraveling Oxidative Stress Resistance: Molecular Properties Govern Proteome Vulnerability

Roger L. Chang, Julian A. Stanley, Matthew C. Robinson…·Sabine Matallana‐Surget

The paper identifies molecular properties that determine oxidative stress resistance in bacteria by analyzing protein susceptibility to oxidation in Escherichia coli and Deinococcus radiodurans.

1 citation

E. coliDrosophila

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