Blake T. Hovde

Metabolic trade-offs in response to increased acetate metabolism in Escherichia coli

This study evolves Escherichia coli to improve acetate metabolism but finds that some mutations reduce growth on glucose, highlighting potential trade-offs in complex feedstocks.

The telomere-to-telomere, gapless, phased diploid genome and methylome of the green alga Scenedesmus obliquus UTEX 3031 reveals significant heterozygosity and functional separation of the haplotypes

The paper presents a gapless, phased diploid genome and methylome of Scenedesmus obliquus, revealing haplotype heterogeneity and functional divergence.

New human chromosomal safe harbor sites for genome engineering with CRISPR/Cas9, TAL effector and homing endonucleases

The paper identifies 35 new human safe harbor sites for genome engineering and validates their utility through experimental tests and toolkit development.