Cancer BiologybioRxivPreprint
Dual Targeting of MAPK Signaling and Senescence-Associated Survival Pathways Overcomes Vincristine Resistance in Fusion-Negative Rhabdomyosarcoma
Yadong Wang, Andrea D. Largent, Eleanor Y. Chen
This paper identifies MAPK signaling and MYC-driven suppression of p21 as mechanisms of vincristine resistance in fusion-negative rhabdomyosarcoma and shows that dual targeting of MAPK and BCL-XL pathways overcomes resistance.
DOI 10.1101/2025.07.29.667542