Author

Hélène Ruffieux

École Polytechnique Fédérale de LausanneORCID 0000-0002-7113-2540Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:Bayesian inference· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anthony C. DavisoniD· 1 shared Armand ValsesiaiD· 1 shared Arne Vernon AstrupiD· 1 shared Benjamin Peter FairfaxiD· 1 shared Chris WallaceiD· 1 shared Elena VigoritoiD· 1 shared Isar NassiriiD· 1 shared Jérôme CarayoliD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenetics

Anthony C. DavisonORCID

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2 papers

Recent·Most cited

EPISPOT: an epigenome-driven approach for detecting and interpreting hotspots in molecular QTL studies

Hélène Ruffieux, Benjamin Peter Fairfax, Isar Nassiri, Elena Vigorito, Chris Wallace, Sylvia T. Richardson, Leonardo Bottolo

EPISPOT improves molecular QTL mapping by integrating epigenetic annotations to detect and interpret genetic hotspots with greater statistical power and biological insight.

The American Journal of Human Genetics · May 1, 2021Peer-reviewedGenetics

A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma

Hélène Ruffieux, Jérôme Carayol, Radu Popescu, Mary‐Ellen Harper, Robert Dent, Wim H. M. Saris, Arne Vernon Astrup, Jörg Hager, Anthony C. Davison, Armand Valsesia

This paper introduces a Bayesian method to map protein abundance QTLs in plasma, identifying replicated associations and demonstrating increased statistical power over univariate approaches.

bioRxiv · May 23, 2020 · PreprintGenetics