Benjamin Peter Fairfax

This paper introduces scTAPAS, a method to reconstruct donor genotypes from scRNA-seq data, enabling eQTL and HLA-TCR analysis without conventional genotyping.

The paper identifies four genome-wide significant loci affecting monocyte cytokine release and links genetic variants to cytokine secretion patterns.

This study shows TMEM33 limits progenitor-exhausted CD8+ T cells, enhances anti-tumor responses, and correlates with improved survival in melanoma patients.

The paper identifies genetic determinants of CD8+ T cell receptor (TCR) repertoire in cancer patients before and after immune checkpoint blockade (ICB) treatment, finding associations with HLA alleles and treatment response.

The paper characterizes genetic determinants of context-specific DNA methylation in primary monocytes exposed to inflammatory stimuli, identifying 209 CpGs under genetic control and linking them to disease.

The paper identifies eQTL specific to NK cells and links them to autoimmunity through transcriptome-wide association studies.

The paper uses blood eQTL meta-analysis to explore the polygenic architecture of complex traits, finding that trans-eQTLs are more informative for identifying causal genes than cis-eQTLs.

EPISPOT improves molecular QTL mapping by integrating epigenetic annotations to detect and interpret genetic hotspots with greater statistical power and biological insight.

The paper investigates how a genetic variant affects IL7R expression and soluble receptor secretion in monocytes under inflammatory conditions.

This study identifies a haplotype lowering PU.1 expression in myeloid cells that delays Alzheimer’s disease onset by affecting gene expression and function.