Arne Elofsson

The paper introduces PconsFold2, a pipeline that improves protein structure prediction by integrating contact predictions and model quality assessment, identifying 558 Pfam families with 90% specificity.

PconsC3 improves contact prediction for small protein families, enabling accurate structure modeling for thousands of Pfam domains.

The paper investigates the folding mechanism of Aquaporin 1, showing that helix 3 can shift out of the membrane core, supporting a more complex folding pathway.

The study shows that the positive inside rule enhances translocon recognition of marginally hydrophobic transmembrane helices when followed by a transmembrane helix, but is not sufficient alone.