Olivier Poch

The paper investigates whether 5' regions of human protein-coding genes contain blueprints for alternative splicing by comparing genes with multiple and single transcript isoforms.

TransStop predicts translational readthrough efficacy for multiple drugs using a transformer-based model trained on PTCs and readthrough compounds.

The paper evaluates missense variant effect predictors using CAGI6 data, finding strong performance across settings and highlighting biases in some predictors.

IMPatienT is a web application that digitizes, processes, and explores multimodal patient data, enabling EDA and diagnosis suggestions through a modular architecture.

The paper identifies that most MHD-only fungal TFs lack a DNA binding domain due to annotation errors, redefining the CeGAL family as a new TF family with Zn2C6-MHD domains.

The paper investigates the role of X circular code motifs in gene expression regulation, finding correlations with optimal codons and demonstrating their predictive power for gene expression levels.

The paper introduces a computational tool to identify potential ORFs in coronavirus genomes, finding overlapping ORFs in SARS-CoV-2 and related viruses and predicting non-functional ORF3b.