Hippocampal protein aggregation signatures fully distinguish pathogenic and wildtype UBQLN2 in amyotrophic lateral sclerosis
Kyrah M. Thumbadoo, Birger Victor Dieriks, Helen C. Murray, Molly E. V. Swanson, Ji Hun Yoo, Nasim F. Mehrabi, Clinton P. Turner, Michael Dragunow, Richard L. M. Faull, Maurice A. Curtis, Teepu Siddique, Christopher E. Shaw, Lyndal Henden, Kelly L. Williams, Garth A. Nicholson, Emma L. Scotter
The paper identifies a hippocampal protein aggregation signature that distinguishes pathogenic from wildtype UBQLN2 in ALS/FTD cases.
bioRxiv · Jan 12, 2022 · PreprintNeuroscience