NeurosciencebioRxivPreprint
N-terminal mutant Huntingtin deposition correlates with CAG repeat length and disease onset, but not neuronal loss in Huntington's disease
Florence E. Layburn, Adelie Y. S. Tan, Nasim F. Mehrabi…·Malvindar K. Singh‐Bains
This study screens antibodies against huntingtin (Htt) to analyze Htt distribution and aggregates in HD brain tissue, finding correlations between CAG repeat length and Htt aggregation, but not neuronal loss.
DOI 10.1101/2022.05.03.490349