Adaptive immunity shapes innate and epithelial cell landscapes by silencing tonic IFN-gamma in innate lymphoid cells during homeostasis.
Ousséma Mejri, Li Ma, Amneh Aoudi, Ossama Labiad, Stanislas Mondot, Ramdane Igalouzene, Clément Codan, Héctor Hernández‐Vargas, Noëmi Rousseaux, Nicolas Lapaque, Stéphane Paul, Thierry Walzer, Julien C. Marie, Saïdi M. Soudja
The paper shows adaptive immunity limits IFN-gamma-driven changes in innate and epithelial cells during homeostasis by suppressing ILC-type 1 polarization.
bioRxiv · Sep 19, 2024 · PreprintImmunology