Héctor Hernández‐Vargas

Atypical contribution of caspase-3 to melanoma cancer cell motility by regulation of coronin 1B activity

This study identifies a non-apoptotic role for caspase-3 in melanoma cell motility by regulating coronin 1B activity, suggesting it as a potential target for anti-metastatic therapies.

Characterisation of CD4 Th subsets as well as dietary, exercise and lifestyle factors in an established Rheumatoid Arthritis cohort; pilot study.

This study examines sex-specific differences in CD4 Th subsets and lifestyle factors in a RA cohort, finding sex-related variations in Th cell frequencies and dietary patterns.

Adaptive immunity shapes innate and epithelial cell landscapes by silencing tonic IFN-gamma in innate lymphoid cells during homeostasis.

The paper shows adaptive immunity limits IFN-gamma-driven changes in innate and epithelial cells during homeostasis by suppressing ILC-type 1 polarization.

MYC shapes ER-mitochondria calcium transfer by directly targeting ITPR1: implications for MYC-induced safeguard mechanisms and cancer

This study shows MYC regulates ITPR1 to control ER-mitochondria calcium transfer, inducing cell death in normal cells but exploited by cancer cells for survival.

Helicases DDX5 and DDX17 promote Hepatitis B Virus transcription termination heterogeneity in infected human hepatocytes

The paper identifies DDX5 and DDX17 as factors promoting HBV transcriptional readthrough and affecting viral RNA stability and replication.

Single cell analysis of the dorsal V-SVZ reveals differential quiescence of postnatal pallial and subpallial neural stem cells driven by TGFbeta/BMP-signalling

The paper uses single-cell RNA-sequencing to identify quiescent neural stem cells in the dorsal V-SVZ and shows that TGFbeta/BMP signalling drives their quiescence and blocks glutamatergic neurogenesis.

Minimal detection and low biological fluctuation of mitochondrial CpG methylation at the single-molecule level

This study develops a tool to detect mtDNA CpG methylation using long-read sequencing and finds low, stable levels across biological processes with limited variation.

Epigenetic heterogeneity after de novo assembly of native full-length Hepatitis B Virus genomes

The paper develops a method to detect 5mCpG in HBV genomes without bisulfite conversion, enabling de novo assembly and identification of epigenetic clusters in infected patients.

The DNA Methylome of Inflammatory Bowel Disease (IBD) reflects intrinsic and extrinsic factors in intestinal epithelial cells

This study identifies DNA methylation changes in IBD linked to both genetic and environmental factors through meta-analysis of intestinal epithelial cell data.

Genome-wide 5-hydroxymethylcytosine (5hmC) emerges at early stage of in vitro hepatocyte differentiation

The paper shows that 5-hydroxymethylcytosine (5hmC) increases genome-wide during early hepatocyte differentiation and its modulation affects hepatic identity markers.