On the utilisation and characterisation of external biotransformation systems in in vitro toxicology: a critical review of the scientific literature with guidance recommendations
Sebastian Lungu-Mitea, Matilda Stein Åslund, Inska S. Reichstein, Felipe Augusto Pinto-Vidal, Andreas Schiwy, Henner Hollert, Miriam Naomi Jacobs, Klára Hilscherová
This paper reviews biotransformation systems in in vitro toxicology, identifies methodological issues, and provides guidance to improve their reliability and integration into regulatory assessments.
bioRxiv · Sep 23, 2025 · PreprintPharmacology & Toxicology