Author

Miriam Naomi Jacobs

UK Health Security AgencyORCID 0000-0002-4858-0118Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 3 Approach:experimental assay· 2 Organism:human· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Agnès JaminiD· 1 shared Andreas SchiwyiD· 1 shared Barbara KubíčkováiD· 1 shared Daniel ZalkoiD· 1 shared Elodie PersoniD· 1 shared Emma Quartermain· 1 shared Felipe Augusto Pinto-VidaliD· 1 shared Henner HollertiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperPharmacology & Toxicology

Agnès JaminORCID

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Author profile →

3 papers

Recent·Most cited

Chemical augmentation of the validated HepaRGTM CYP induction test method Part 2: Additional laboratory study supported by mRNA analysis

Emma Quartermain, Jinkang Zhang, Tim H. Marczylo, Timothy W. Gant, Miriam Naomi Jacobs

A third laboratory transferred the HepaRG CYP induction assay to six augmentation and four additional non-pharmaceutical chemicals; parallel mRNA data supported enzyme activity calls, with CYP3A4 most concordant.

bioRxiv · Jun 20, 2026 · PreprintPharmacology & Toxicology✦ In-depth digest

Chemical augmentation of the validated HepaRGTM CYP enzyme induction test method Part 1: The Goliath two laboratory study

Miriam Naomi Jacobs, Barbara Kubíčková, Elodie Person, Jorke Harmen Kamstra, Nicolas J. Cabaton, Sebastian Hoffmann, Agnès Jamin, Marlène Z. Lacroix, Juliette Legler, Vesna Munić Kos, Sandra M. Nijmeijer, Theo L. Sinnige, Laurie Urien, Daniel Zalko

This paper validates the HepaRG CYP enzyme induction test method for pharmaceutical and non-pharmaceutical chemicals, showing good reproducibility for pharmaceuticals but less consistency for non-pharmaceuticals.

bioRxiv · Jun 20, 2026 · PreprintPharmacology & Toxicology

On the utilisation and characterisation of external biotransformation systems in in vitro toxicology: a critical review of the scientific literature with guidance recommendations

Sebastian Lungu-Mitea, Matilda Stein Åslund, Inska S. Reichstein, Felipe Augusto Pinto-Vidal, Andreas Schiwy, Henner Hollert, Miriam Naomi Jacobs, Klára Hilscherová

This paper reviews biotransformation systems in in vitro toxicology, identifies methodological issues, and provides guidance to improve their reliability and integration into regulatory assessments.

bioRxiv · Sep 23, 2025 · PreprintPharmacology & Toxicology