A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis
Lai Jiang, Shujing Xu, Nicholas Mancuso, Paul J. Newcombe, David V. Conti
This paper introduces hJAM, a hierarchical model that improves causal inference in Mendelian randomization and transcriptome-wide association studies by incorporating prior information and accounting for SNP correlations.
American Journal of Epidemiology · Dec 29, 2020Peer-reviewedGenetics