Yunpeng Wang

This study identifies how different environmental factors affect cortical architecture in twins, showing persistent early life effects and training-induced changes in adulthood.

The paper quantifies genetic influences across educational milestones in two Norwegian cohorts, finding stage-specific heritability and declining genetic overlap with later degrees.

The paper shows cortical thickness changes occur years before high amyloid levels in Alzheimer's disease, challenging the view that amyloid is the first imaging marker.

The paper investigates the genetic and epigenetic factors underlying childhood internalizing and externalizing problems and their co-occurrence using GWAS, PGS, and EWAS in a large cohort.

This study conducts a genome-wide association analysis to identify genetic factors influencing growth and metabolic traits in duckweed, revealing correlations between biomass and specific metabolites.

The paper shows that higher genetic risk for Alzheimer's disease is linked to faster brain volume loss and memory decline in healthy adults.

The paper investigates the effects of short sleep on brain structure and cognitive function, finding that short sleepers without daytime tiredness have larger brain volumes but slightly lower cognitive scores.

The paper analyzes cortical asymmetry across age and datasets, finding stable areal asymmetry and developmental changes in thickness asymmetry, with genetic and phenotypic associations.

The paper estimates brain age gap (BAG) using neural networks and identifies eight genomic regions associated with BAG, finding causal relationships with Alzheimer's and bipolar disorder but not Parkinson's, depression, or schizophrenia.

This study shows that birth weight consistently correlates with cortical surface area and volume across the lifespan, suggesting prenatal growth influences brain structure through brain reserve rather than maintenance.

The paper investigates how general cognitive ability relates to cortical brain volume changes over time, finding associations with both brain reserve and maintenance mechanisms.

This study examines the relationship between sleep duration and brain structure using MRI data, finding that 6.8 hours of sleep is associated with the most favorable brain outcomes, with genetic analyses suggesting homeostatic regulation of sleep duration.

This study finds that adult brain age is more influenced by early life factors like birth weight and polygenic scores than by longitudinal brain decline.

The paper examines how education and income relate to brain and cognitive differences across European and US cohorts, finding heterogeneous effects and stronger associations in US samples.

This study finds that worse self-reported sleep relates to faster hippocampal microstructural decline in β-amyloid positive adults, independent of genetic risk.

deMeta removes the effect of a sub-study from GWAS meta-analysis results using only summary statistics, enabling efficient correction of overlapping samples.

This study shows genetic risk for Alzheimer's disease affects hippocampal volume throughout life in a healthy population.

This paper identifies stable developmental clusters of subcortical volumetric change across the lifespan and shows genetic organization within these clusters.

The paper identifies genetic loci associated with variability in brain volumes and thickness, showing they are distinct from loci affecting mean volumes.

The paper examines common genetic variants' contribution to bipolar disorder risk in multiplex families and finds higher polygenic risk scores in affected individuals compared to controls and unaffected family members.

This study identifies 73 genome-wide significant loci for mood disorders, revealing shared and distinct genetic factors between major depressive disorder and bipolar disorder.

The paper examines the relationship between sleep problems and amyloid deposition in cortical regions with high HOMER1 expression in older adults, finding a stronger link in younger participants and regions with high HOMER1 expression.

MiXeR quantifies polygenic overlap between complex traits using GWAS summary statistics, revealing shared causal variants beyond genetic correlation.

This study identifies 30 genome-wide significant loci associated with bipolar disorder, including novel genes involved in ion channels, neurotransmitters, and synaptic components.

The paper examines how autozygosity and schizophrenia polygenic risk scores relate to cognitive and brain development in a population cohort.

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

This study identifies 9 novel genetic loci and 215 potential causative genes associated with Alzheimer's disease risk through a large genome-wide association analysis.

This study identifies genetic overlaps between frontotemporal dementia and immune-mediated diseases, finding strong enrichment with rheumatoid arthritis and moderate enrichment with other immune conditions.

This paper introduces a covariate-modulated local false discovery rate method for GWAS to improve power and pathway analysis for schizophrenia.

The paper identifies a brain white matter pattern linked to heritable cognitive and psychopathology factors in youth using data from the PNC sample.