Large-scale single-cell mapping of concealed mitochondrial ageing
Hetvi Jethwani, Kamal Khairudin Sukandar, Alistair P. Green, Ferdinando Insalata, Zoe J. Golder, Katherine R. Schon, Becca Asquith, Patrick Francis Chinnery, Nick S. Jones
The paper maps concealed mitochondrial DNA mutations across 2.7 million cells from 311 individuals, finding that low-prevalence mutations accumulate with age and predict human age.
bioRxiv · Jul 20, 2026 · PreprintGenomics