Alistair P. Green

Large-scale single-cell mapping of concealed mitochondrial ageing

The paper maps concealed mitochondrial DNA mutations across 2.7 million cells from 311 individuals, finding that low-prevalence mutations accumulate with age and predict human age.

Cryptic mitochondrial ageing coincides with mid-late life and is pathophysiologically informative in single cells across tissues and species

The paper identifies cryptic mitochondrial DNA mutations in single cells across species and tissues, showing their association with ageing and pathophysiological processes.

Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development

The paper identifies mitochondrial defects in eliminated cells during early mouse development and shows that cell competition removes cells with mitochondrial DNA mutations and sequence changes.