ToolsGenie 2.0 automates bioinformatics analyses using a multi-agent AI framework, achieving 68.6% accuracy on an in-house dataset and 48.3% on BixBench.

bioRxiv · Jan 7, 2026 · PreprintBioinformatics

PromptBio: A Multi-Agent AI Platform for Bioinformatics Data Analysis

Minzhe Zhang, Wenhao Gu, Bo‐Wei Han, Vincent Guo, Chintan Addoni, Jiayu Chen, Youjia Ma, Yang Leng, Kai Li, Xiaoxi Lin, Shi Shi, Junbin Zheng, Yilin Zheng, Weiying Wang, Linlin Wu, , Xiao Yang

PromptBio introduces a multi-agent AI platform for scalable, reproducible bioinformatics analysis using generative AI and natural language interaction.

bioRxiv · Jul 5, 2025 · PreprintBioinformatics

Whole-Genome Promoter Profiling of Plasma Cell-Free DNA Exhibits Predictive Value for Preterm Birth

Zhiwei Guo, Ke Wang, Xiang Huang, Kun Li, Guojun Ouyang, Xu Yang, Jiayu Tan, Haihong Shi, Liangping Luo, Xincai Zhang, Min Zhang, Bo‐Wei Han, Xiang-Ming Zhai, Yingsong Wu, Fang Yang, , Jia Tang

The paper develops a classifier, PTerm, using whole-genome promoter profiling of plasma cell-free DNA to predict preterm birth with high accuracy across multiple validation cohorts.

medRxiv · Sep 20, 2022 · PreprintGenetic & Genomic Medicine