A humanized ossicle model of myelofibrosis reveals THPO-driven fibrosis, osteosclerosis and SPP1-dependent microenvironmental remodeling
Hongzhe Li, Alba Lillo Sierras, Rong Fan, Michaela Oeller, Katharina Schallmoser, Anne Hultquist, Stefan Scheding
This paper develops a humanized myelofibrosis model to show THPO drives fibrosis, osteosclerosis, and SPP1-dependent niche remodeling, suggesting SPP1 as a therapeutic target.
bioRxiv · Apr 11, 2026 · PreprintCancer Biology