Rong Fan

Loss of ASIC1A-dependent inhibitory neuron activity in basolateral amygdala is associated with increased CO2-evoked jumping

This study shows that loss of ASIC1A in the basolateral amygdala increases CO2-evoked jumping and reduces freezing in mice.

A humanized ossicle model of myelofibrosis reveals THPO-driven fibrosis, osteosclerosis and SPP1-dependent microenvironmental remodeling

This paper develops a humanized myelofibrosis model to show THPO drives fibrosis, osteosclerosis, and SPP1-dependent niche remodeling, suggesting SPP1 as a therapeutic target.

3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

The paper presents a 3D multi-omic framework to detect and characterize ovarian cancer precursors in fallopian tubes, identifying TP53 mutations in microscopic lesions.

Combined multi-color immunofluorescence staining and spatial in situ mRNA expression analysis identifies potential fibrosis drivers in acute lymphoblastic leukemia

The paper identifies TGFB1 and PDGFA1 as potential fibrosis drivers in pediatric ALL by combining spatial RNA and immunofluorescence analysis.

Carbonic anhydrase 4 disruption and pharmacological inhibition reduce synaptic and behavioral adaptations following oxycodone withdrawal

This study shows that disrupting or inhibiting carbonic anhydrase 4 reduces synaptic and behavioral adaptations during oxycodone withdrawal in mice.

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.

Identification and verification of 3 key genes associated with survival and prognosis of patients with colon adenocarcinoma via integrated bioinformatics analysis

The paper identifies and verifies three genes associated with survival in colon adenocarcinoma using integrated bioinformatics analysis of gene expression data.