Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation
Sarah Lusk, Sarah LaPotin, Jason S. Presnell, Kristen M. Kwan
The paper shows overactive Hedgehog signaling in zebrafish ptch2 mutants increases Netrin expression, leading to coloboma, while Netrin loss does not rescue the phenotype.
Developmental Dynamics · Aug 21, 2024Peer-reviewedDevelopmental Biology