Phillip A. Cleves

Aiptasia larvae are phenotypically validated as a model of coral bleaching using high-throughput machine-learning image analysis

This paper validates Aiptasia larvae as a coral bleaching model and introduces SYMPHONY, an ML pipeline that efficiently identifies algal localization in larvae under heat stress.

Co-option of lysosomal machinery shapes the symbiosis supporting coral reefs

The paper identifies lysosomal protein co-option in symbiosomes of coral and anemone models, showing its role in supporting photosymbiosis through carbon-concentrating and sulfate transport mechanisms.

CRISPR/Cas9-mutagenesis reveals that varying dependence on HSF1 is associated with differences in coral heat tolerance

The paper uses CRISPR/Cas9 to show that heat-tolerant corals rely less on HSF1 for survival during heat stress compared to heat-sensitive corals.

Global coral genomic vulnerability explains recent reef losses

The paper identifies genomic vulnerability in Acropora corals by linking heat-adapted genotypes to reef decline and predicts future genetic diversity loss due to ocean warming.

Lipid nanoparticle supplementation enhances host metabolism in a model symbiotic cnidarian

This study shows lipid nanoparticles (LNPs) enhance lipid metabolism and suppress reproduction in cnidarians, suggesting their potential for coral aquaculture.

Multigenerational Tracking of Reef-Building Corals Using CRISPR-Cas9induced Genetic Barcodes and eDNA Metabarcoding

The paper introduces a method to track coral individuals and their offspring over time using CRISPR-Cas9 genetic barcodes and eDNA metabarcoding.

Cross-Species Biomechanical Determinants of Shape Diversity

The paper identifies biomechanical modules that govern larval shape diversity across six cnidarian species and shows how manipulating these modules can transform shapes between species.

Molecular insights into the Darwin paradox of coral reefs from the sea anemone Aiptasia

The paper shows that glucose from symbiotic algae supports nitrogen assimilation in Aiptasia, enabling survival in nutrient-poor environments.

Varied effects of algal symbionts on transcription factor NF-κB in a sea anemone and a coral: possible roles in symbiosis and thermotolerance

The paper investigates the role of NF-κB in cnidarian-algal symbiosis and thermotolerance in Aiptasia and Pocillopora damicornis, showing differential expression and effects on survival and bleaching.