A biatrial digital twin integrating electrophysiology, mechanics, and circulation: from physiology to atrial fibrillation
Sergi Pico-Cabiro, Alberto Zingaro, Violeta Puche-García, Dimitrios I. Lialios, Mariano Vázquez, Blas Echebarria, Maite Izquierdo, Francesc Carreras, Javier Sáiz, Eva Casoni
This paper presents a multiscale atrial digital twin framework that integrates electrophysiology, mechanics, and circulation to simulate normal and pathological atrial function, showing how electrical changes affect mechanical and hemodynamic outcomes.
bioRxiv · Mar 19, 2026 · PreprintBioengineering