Violeta Puche-García

This study shows that antiarrhythmic drug efficacy in atrial fibrillation depends on patient-specific electrophysiological substrates and rotor dynamics, with drug-induced frequency reduction being a key mechanism.

This paper presents a multiscale atrial digital twin framework that integrates electrophysiology, mechanics, and circulation to simulate normal and pathological atrial function, showing how electrical changes affect mechanical and hemodynamic outcomes.