Blas Echebarria

The paper develops a 3D computational model of mouse ventricular myocytes to show that calsequestrin2 (CASQ2) co-localization with RyR2 clusters is essential for reliable calcium wave propagation.

This paper presents a multiscale atrial digital twin framework that integrates electrophysiology, mechanics, and circulation to simulate normal and pathological atrial function, showing how electrical changes affect mechanical and hemodynamic outcomes.

The paper uses a two-variable nullcline analysis to predict calcium homeostasis in ventricular myocytes and explains why SERCA gene therapy may fail to improve contraction despite increasing SERCA expression.