Author

David Altshuler

Broad InstituteORCID 0000-0002-7250-4107Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 2 Organism:human· 2 Approach:statistical model· 2 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Aarno V. PalotieiD· 1 shared Adam KieżuniD· 1 shared Alan Kwong· 1 shared Alexander StratigosiD· 1 shared Aliki‐Eleni FarmakiiD· 1 shared Amit Joshi· 1 shared Andrea AngiusiD· 1 shared Andrew Tan ChaniD· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Aarno V. PalotieORCID

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2 papers

Recent·Most cited

Case-control analysis identifies shared properties of rare germline variation in cancer predisposing genes

Mykyta Artomov, Joseph Vijai, Grace Tiao, Tinu Thomas, Kasmintan A. Schrader, Robert J. Klein, Adam Kieżun, Namrata Gupta, Lauren Margolin, Alexander Stratigos, Ivana K. Kim, Kristen Shannon, Leif William Ellisen, Daniel A. Haber, Gad A. Getz, , Mark J. Daly

The paper analyzes rare germline variation in cancer predisposing genes across cancer patients and controls to identify shared mutation properties and candidate susceptibility genes.

European Journal of Human Genetics · Feb 4, 2019Peer-reviewedGenetics

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

Luke M. Evans, Rasool Tahmasbi, Matthew Jones, Scott I. Vrieze, Gonçalo R. Abecasis, Sayantan Das, Douglas W. Bjelland, Teresa R de Candia, David Altshuler, Carl A. Anderson, Andrea Angius, Jeffrey C. Barrett, Sonja I. Berndt, Michael Boehnke, Dorrett Boomsma, , George Davey Smith

This paper estimates narrow-sense heritability using identity-by-descent information in unrelated individuals and finds that IBD-based methods can capture rare variant contributions but are affected by stratification.

Heredity · Mar 28, 2018Peer-reviewedGenetics