Astrocytic glycolysis attenuates mitochondrial efficiency to preserve cognition
Paula Alonso-Batan, Daniel Jiménez-Blasco, Jesús Agulla, Rebeca Lapresa, Marta Antequera-Duwell, Sara Yunta-Sanchez, Brenda Morant-Ferrando, Darío García-Rodríguez, Rebeca Acín‐Pérez, Verónica Bobo-Jiménez, Leticia Sancha-Ortega, Regina Mengual, Silvia Gomila, Sonia González-Guerrero, E J García Fernández, , Juan Pedro Bolaños
This study identifies Pfkfb3 as essential for astrocytic glycolysis, which preserves cognition by reducing mitochondrial efficiency and redirecting pyruvate to neurons.
bioRxiv · Dec 26, 2025 · PreprintCell Biology