Daniel Jiménez-Blasco

The paper identifies a female-specific microglial redox program that influences susceptibility to obesity by modulating metabolic resilience and mTORC1 signaling.

This study shows that mitochondrial pyruvate import in astrocytes is essential for maintaining neurotransmitter homeostasis and seizure resistance, rather than primarily for bioenergetic purposes.

This study identifies Pfkfb3 as essential for astrocytic glycolysis, which preserves cognition by reducing mitochondrial efficiency and redirecting pyruvate to neurons.

This study shows TET3 regulates terminal differentiation by affecting mitochondrial metabolic maturation and oxidative phosphorylation in intestinal epithelial cells.

This study identifies a metabolic shift driven by PFKFB3 in CLN7 disease, showing that targeting glycolysis can alleviate disease hallmarks in a mouse model and patient-derived cells.

This study shows that inhibiting PFKFB3 in neurons prevents redox stress and neuronal death in ischemia-reperfusion injury, and reduces brain damage in mice.