Adam Streck

Haplotype-resolved genome architecture mapping uncovers pervasive structural heterogeneity between human homologous chromosomes

The paper introduces CoPhasing, a method to phase chromatin contacts with haplotype specificity, revealing structural differences between homologous chromosomes.

Deciphering selection patterns of somatic copy-number events

This paper introduces SPICE, a framework to infer copy-number events and model selection in cancer genomes, revealing 460 loci under selection and expanding the known cancer-related loci.

Path integration impairments reveal early cognitive changes in Subjective Cognitive Decline

This study identifies path integration impairments in individuals with subjective cognitive decline, suggesting memory leak as an early marker of neurodegeneration related to Alzheimer's disease.

CNSistent integration and feature extraction from somatic copy number profiles

CNSistent integrates and analyzes somatic copy number profiles across cancer cohorts to improve classification accuracy and identify key alterations.

SMITH: Spatially Constrained Stochastic Model for Simulation of Intra-Tumour Heterogeneity

SMITH simulates cancer evolution with spatial constraints, showing that confinement mechanisms can reproduce clonal dynamics efficiently.