Thomas Wolbers

This study shows that unstable hexadirectional signals in the entorhinal cortex of older adults correlate with poorer memory and reduced signal strength, suggesting grid-like coding instability rather than absence.

The paper investigates how tau accumulation in the entorhinal cortex affects episodic memory by analyzing grid-cell-like signals in older adults using MRI and tau PET.

This study investigates the distinct cognitive and neural mechanisms underlying path integration and spatial updating in humans using behavioral and fMRI experiments.

This paper develops a rodent version of the Triangle Completion Task to improve cross-species comparability in path integration studies.

This study investigates how aging affects the head direction network using virtual reality experiments and computational models, finding that aging increases angular errors and heading uncertainty due to noise and neuron loss.

This study investigates how aging affects the use and neural representation of environmental boundary information during spatial memory tasks using fMRI.

This study identifies path integration impairments in individuals with subjective cognitive decline, suggesting memory leak as an early marker of neurodegeneration related to Alzheimer's disease.

This study shows the hippocampus integrates spatial cues during navigation, with stronger positional coding when combining landmarks and self-motion cues, suggesting a role beyond simple spatial representation.

The paper uses 7T MRI to analyze 3D structural features in the human hand area of S1 and finds no topographic organization, unlike in some monkeys.

The paper shows that midlife path integration impairments predict Alzheimer's disease risk, independent of other cognitive tests.

The paper investigates spatial representations in human retrosplenial cortex and hippocampus during navigation, finding both cue-specific and cue-independent representations in RSC.

The paper reanalyses fMRI data to investigate global and local head direction coding in humans, finding distinct brain regions code for different reference frames.

This study investigates age-related cognitive mapping deficits using behavioral and fMRI data, finding increased hippocampal excitability and altered learning dynamics in older adults.

This study examines de-differentiated topographic maps in somatosensory cortex of younger and older adults using fMRI and behavioral tests, finding that reduced representational similarity and altered cortical distances correlate with specific behavioral changes.

This study identifies noise and speed estimation bias as primary sources of path integration errors in young and aging humans, showing age-related declines are linked to increased unbiased noise.

This study uses fMRI and multivariate decoding to show allocentric boundary and goal direction coding in human entorhinal cortex and subiculum.

This study shows that hippocampal volume predicts egocentric distance coding to a local landmark during navigation, with stronger effects when path integration relies on body-based cues.

The paper introduces GridCAT, a Matlab-based toolbox for automated analysis of grid cell codes in fMRI data, providing a GUI and open-source code for grid code estimation, fitting, and visualization.