Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics
Shreya Johri, Kevin Bi, Breanna M. Titchen, Jingxin Fu, Jake R. Conway, Jett P. Crowdis, Natalie I. Vokes, Zenghua Fan, Lawrence H. Fong, Jihye Park, David Liu, Meng Xiao He, Eliezer M. Van Allen
The paper introduces BEANIE, a nonparametric method to improve differential enrichment analysis in single-cell transcriptomics by accounting for sample-specific biology and robustness of signatures across cohorts.
Nature Communications · Mar 1, 2025Peer-reviewedBioinformatics